In this primer, we illustrate the principles behind FBA by applying it to predict the maximum growth rate of Escherichia coli in the presence and absence of oxygen. The principles outlined can be ...

Conservation levels of gene expression abundance ratios are globally coordinated in cells, and cellular state changes under such biologically relevant stoichiometric constraints are readable as ...

Edited by Mark H. Thiemens, University of California San Diego, La Jolla, CA, and approved February 28, 2020 (received for review October 9, 2019) ...