心肌梗死（Myocardial Infarction，MI）会导致心肌细胞不可逆的损失和不良重塑，最终发展为心力衰竭（Heart Failure，HF）。尽管基于基因和 RNA 的疗法为心脏修复提供了有前景的策略，但目前的方法往往依赖于侵入性的心肌递送，或者受到传统 mRNA 表达持续时间短和 ...

该研究发现使用RNA引导的桥接重组酶在人类细胞中进行可编程基因组编辑。 基因大小的DNA片段的位点特异性插入仍然是基因组编辑领域未满足的需求。IS110家族丝氨酸重组酶最近被证明使用同时识别靶和供体位点的双特异性RNA向导（桥接RNA）介导细菌中可编程的 ...

A team at UT Southwestern Medical Center has identified a structural trick that lets viruses translate their genetic code inside human cells, even when that code is riddled with “bad” codons the host ...

Neurodegenerative diseases are commonly adult-onset conditions characterized by degeneration of specific neuronal populations. Familial forms are caused by mutations in single genes, but most patients ...

该研究开发了一种脂质纳米颗粒递送的自复制 RNA 疗法，只需单次肌肉注射，即可在体内持续表达心脏保护因子，显著改善心肌梗死后的心脏功能和心室重构。 心肌梗死（Myocardial Infarction，MI）会导致心肌细胞不可逆的损失和不良重塑，最终发展为心力衰竭（Heart ...

Early in the coronavirus disease 2019 (COVID-19) pandemic, it was clear that quick and accurate diagnostic techniques were required to deal with emerging infections and offset the negative impacts of ...