Metabolic reprogramming and circadian disruption drive cellular senescence. Discover how repurposing vutiglabridin to target ...

Aerobic glycolysis dominates lesion bioenergetics, with lactate promoting histone lactylation, M2 macrophage polarization, ...

Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center for Cancer Biology and ...

Metabolic reprogramming in fibrotic lung diseases involves key metabolites like lactate, succinate, and 2-hydroxyglutarate, driving inflammation and fibroblast activation. Lactate accumulation ...

Breast cancer development is not solely the result of cancer cells acting independently, it involves a dynamic and complex ecosystem composed of cancer cells, immune cells, fibroblasts, adipocytes, ...

Tumor growth unfolds within a tumor microenvironment (TME) defined by metabolic–immune crosstalk. Emerging evidence indicates that cancer cells not only reprogram glycolysis but also alter amino acid, ...

A recent study has demonstrated the power of metabolic engineering in enhancing the antitumor activity of chimeric antigen receptor (CAR) macrophages (CAR-Ms) in solid tumors. By overexpressing the ...

Potent antitumor activity of the KRASG12D inhibitor MRTX1133 in pancreatic cancer: Augmenting the nanoparticle-paclitaxel chemotherapy response. This is an ASCO Meeting Abstract from the 2025 ASCO ...

BACKGROUND: Pulmonary hypertension (PH) is a serious complication of heart failure with preserved ejection fraction (HFpEF), ...

A metabolic enzyme studied for over seven decades has a hidden second function - it can unwind RNA and promote cell cycle progression, an additional function beyond its role in energy production, ...