Highly potent but poorly water-soluble drug (PWSD) candidates are common outcomes of contemporary drug discovery programmes. These lipophilic compounds often exhibit poor systemic exposure following ...

Orally administered drugs have to pass through the gut wall mucosa before they may reach the capillaries that lead to the portal vein. This barrier consists of polarized enterocytes that are closely ...

Biopharmaceuticals, medium- and high-molecular weight biologically active macromolecules, are not easily absorbed by the small intestine, the main organ responsible for gastrointestinal absorption, ...

Scientists from Central Food Technological Research Institute (CSIR-CFTRI), Mysuru, and Indian Institute of Food Processing Technology (IIFPT), Thanjavur, have developed an artificial small intestine ...

The fact that several substances that function as OATP inhibitors are at the same time inhibitors or inducers of CYP enzymes and other transporters hampers the clarification of an involvement of OATPs ...

New research shows that certain flavonols from everyday foods can shut down the body’s drug-resistance machinery, potentially paving the way for more effective treatments, but clinical hurdles remain.

The way in which the body processes cholesterol affects the risk of cardiovascular diseases. LDL cholesterol is obtained from ...

In this interview, Karl Box discusses how particle drift analysis using flux tools improves oral drug absorption in pharmaceutical research. Can you tell us about Pion’s Rainbow Dynamic Dissolution ...

Medically reviewed by Kumkum S. Patel, MD Key Takeaways Villi are tiny projections in the small intestine that absorb ...