Researchers at the Tokyo Institute of Technology say they have developed a computational method based on large-scale molecular dynamics simulations to predict the cell-membrane permeability of cyclic ...

Scientists have developed a computational method based on large-scale molecular dynamics simulations to predict the cell-membrane permeability of cyclic peptides using a supercomputer. Their protocol ...

Cyclic peptides often exhibit low membrane permeability which can be significantly improved via amide-to-ester substitutions—as demonstrated by researchers from Tokyo Institute of Technology (Tokyo ...