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Science Advances:肖俊宇团队与赵明辉、谭颖团队合作揭示补体系统C3 ...
该研究系统地揭示了补体系统两种C3转化酶的组装机制,同时获得了两种转化酶结合底物C3后形成的“Michaelis”复合物(酶与底物形成的中间体),阐明了补体系统转化酶识别并切割核心组分C3的分子机制。 补体系统是天然免疫的重要组成部分,是人体免疫的第一 ...
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