Indomethacin（Indometacin，AbMole，M3466）是一类经典的小分子环氧合酶（COX）抑制剂，能够通过靶向结合 COX-1与COX-2蛋白，阻断花生四烯酸向前列腺素的转化过程，从而干扰前列腺素介导的下游信号级联反应，在体外细胞模型中实现对炎症相关通路的精准调控[1]。 作为广泛使用的工具化合物，Indomethacin不仅可抑制前列腺素合成，还能影响细胞内氧化还原平衡、离 ...

Anti-inflammatory drugs have long served as a cornerstone in the treatment of conditions marked by inflammation, pain, and fever. At the heart of many of these therapeutic agents lies the inhibition ...

Conventional wisdom holds that nonsteroidal anti-inflammatory drugs (NSAIDs) can trigger disease flares in patients with ...

Antibiotics, antivirals, vaccinations and anti-inflammatory medication are associated with reduced risk of dementia, according to new research that looked at health data from over 130 million ...

Anti-inflammatory medications reduce depressive symptom severity and anhedonia in individuals with depression and elevated levels of inflammation, according to a new study published in the American ...

Alzheimer's disease, the most common cause of dementia, is currently incurable. The current drugs available have very limited efficacy and only in mild stages of the disease. A team from the ...

Gilead Sciences (NASDAQ:GILD) and Danish pharmaceutical company LEO Pharma on Saturday announced an agreement worth up to $1.7B to jointly develop and commercialize LEO’s anti-inflammatory drugs. As ...

A preclinical study finds that a drug already FDA-approved for treating inflammatory conditions may help reduce both alcohol intake and pain sensitivity -- two issues that commonly co-occur with ...

An international research team with the participation of researchers from the University Medical Center Göttingen (UMG), ...

Inflammation is our body’s defense mechanism against phenomena it recognizes as foreign. However, as with any complicated defense system, errors may occur. Inflammation helps our body fight off ...